Drugs & Vitamins

Active Ingredients: Amprenavir
Other Names: Agenerase
Drug Class: Protease Inhibitors
Product Images & Descriptions:

What is/are Agenerase? (Back to top)
AMPRENAVIR is an antiretroviral drug. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.

NOTE: This drug is discontinued in the United States. Patients taking Amprenavir should contact their prescriber regarding discontinuation and alternative therapies. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine? (Back to top)
They need to know if you have any of these conditions:

• hemophilia
• liver disease
• an unusual or allergic reaction to amprenavir, fosamprenavir, sulfa drugs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine? (Back to top)
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food, but do not take it with a high fat meal. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 4 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose? (Back to top)
If you miss a dose by more than 4 hours, wait and take the next dose at the regular time. But, if you miss a dose by less than 4 hours, take your missed dose right away. Then take your next dose at the regular time. Do not take double or extra doses.

What may interact with this medicine? (Back to top)
Do not take this medicine with any of the following:

• astemizole
• bepridil
• cisapride
• delavirdine
• dofetilide
• flecainide
• female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
• medicines for headaches like dihydroergotamine, ergonovine, ergotamine, methylergonovine
• medicines for cholesterol like atorvastatin, cerivastatin, lovastatin, simvastatin
• midazolam
• pimozide
• propafenone
• ranolazine
• red yeast rice
• rifampin
• rifapentine
• triazolam
• St. John's wort
• vitamin E supplements

• amiodarone
• antacids
• cyclosporine
• dexamethasone
• fluticasone
• lidocaine
• medicines for depression, anxiety, or psychotic disturbances
• medicines for fungal infections like ketoconazole and itraconazole
• medicines for blood pressure like amlodipine, diltiazem, verapamil
• medicines for seizures
• methadone
• other medicines for HIV
• quinidine
• rapamycin
• rifabutin
• sildenafil
• sirolimus
• tacrolimus
• warfarin

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine? (Back to top)
Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• redness, blistering, peeling or loosening of the skin, including inside the mouth

• changes in taste
• depressed mood
• diarrhea
• increased hunger or thirst
• increased urination
• nausea, vomiting
• stomach pain
• tingling around the mouth
• unusually weak or tired
• weight gain around waist, back, or thinning of face, arms, legs

This list may not describe all possible side effects.

What should I watch for while using this medicine? (Back to top)
Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Birth control pills, patches, rings, or injections may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.

This medicine contains large amounts of vitamin E. Do not take vitamin supplements that have vitamin E while you are taking this medicine.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Where should I keep this medicine? (Back to top)
Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Last Updated:March 26, 2008

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